
%0 Journal Article
%A Allan, RD 
%A Dickenson, HW 
%A Johnston, GAR 
%A Kazlauskas, R 
%A Tran, HW 
%T Synthesis of Analogues of GABA. XIV. Synthesis and Activity of Unsaturated Derivatives of 5-Aminopentanoic Acid (d-Aminovaleric Acid)
%J Australian Journal of Chemistry
%D 1985/11/01
%V 38
%N 11
%P 1651-1656
%K 
%R https://doi.org/10.1071/CH9851651
%U https://www.publish.csiro.au/paper/CH9851651 
%X The (Z) and (E) pairs of 5-aminopent-2-enoic acid and 5-aminopent-3- enoic acid, as well as the related 5-aminopent-3-ynoic acid, have been prepared for structure-activity studies on GABA receptors. Only the (Z) isomers were active as GABA agonists with (Z)-5-aminopent-2-enoic acid being two- to four-fold more active than 5-aminopentanoic acid. 
