
%0 Journal Article
%A Barlin, GB 
%A Tan, WL 
%T Potential Antimalarials. V. 4-(7&#8242;-Trifluoromethylquinolin-4&#8242;-Ylamino)Phenols, 4-[2&#8242;,7&#8242; and 2',8&#8242;-Bis(Trifluoromethyl)Quinolin-4&#8242;-Ylamino]Phenols and N<sup>4</sup>-Substituted 2,7-(and 2,8-)Bis(Trifluoromethyl)-Quinolin-4-Amines
%J Australian Journal of Chemistry
%D 1985/12/01
%V 38
%N 12
%P 1827-1835
%K 
%R https://doi.org/10.1071/CH9851827
%U https://www.publish.csiro.au/paper/CH9851827 
%X Mono- and di-Mannich bases of 4-(7&#8242;-trifluoromethylquinolin-4&#8242;- ylamino )phenol and its 2&#8242;,7&#8242;- and 2&#8242;,8&#8242;-bis( trifluoromethyl ) analogues, for example 2,6-bis(piperidin-1&#8242;-ylmethyl)-4-(7&#8242;-trifluoromethyl- quinolin-4&#8242;-ylamino)phenol, have been prepared. The Mannich bases from 4-(7&#8242;-trifluoromethyl-quinolin-4&#8242;-ylamino)phenol showed significant antimalarial activity when injected intraperitoneally in a single dose of 100 mg/kg to mice infected with Plasmodium vinckei vinckei ; those from its 2&#8242;,7&#8242;- and 2&#8242;,8&#8242;-bis( trifluoromethyl ) analogues did not show appreciable activity. Some N4-substituted 2,7(and 2,8)- bis ( trifluoromethyl )quinolin-4-amines with aliphatic side chains were also prepared but were inactive. The blood schizontocidal activity of mefloquine was not retained in the 2,8-bis( trifluoromethyl )-quinolin-4-amines prepared here. 
