
%0 Journal Article
%A Heinicke, GW 
%A Morella, AM 
%A Orban, J 
%A Prager, RH 
%A Ward, AD 
%T Central-Nervous-System Active Compounds .XVI. Some Chemistry of 6-Oxo Caprolactams Derived From an Enamine Ring-Expansion Synthesis
%J Australian Journal of Chemistry
%D 1985/12/01
%V 38
%N 12
%P 1847-1856
%K 
%R https://doi.org/10.1071/CH9851847
%U https://www.publish.csiro.au/paper/CH9851847 
%X Several 6-oxo caprolactam derivatives have been prepared by the ring- expansion of enaminopyrrolidones with dimethyl acetylenedicarboxylate . Other acetylenic systems did not react. The products exist in the enol form of the &#946;- keto ester system are are very resistant towards hydrolysis. They react with hydrazine and phenylhydrazine to form pyrazolo [3,4-c] azepinones in low yield. Many of the caprolactams and their pyrazolo -fused derivatives show central nervous system activity of a depressant nature in mice. 
