
TY  - JOUR
A1  - Heinicke, GW 
A1  - Morella, AM 
A1  - Orban, J 
A1  - Prager, RH 
A1  - Ward, AD 
T1  - Central-Nervous-System Active Compounds .XVI. Some Chemistry of 6-Oxo Caprolactams Derived From an Enamine Ring-Expansion Synthesis
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1985
VL  - 38
IS  - 12
SP  - 1847
EP  - 1856
KW  - 
UR  - https://doi.org/10.1071/CH9851847 
N2  - Several 6-oxo caprolactam derivatives have been prepared by the ring- expansion of enaminopyrrolidones with dimethyl acetylenedicarboxylate . Other acetylenic systems did not react. The products exist in the enol form of the &#946;- keto ester system are are very resistant towards hydrolysis. They react with hydrazine and phenylhydrazine to form pyrazolo [3,4-c] azepinones in low yield. Many of the caprolactams and their pyrazolo -fused derivatives show central nervous system activity of a depressant nature in mice. 
ER  -

