
%0 Journal Article
%A Allan, RD 
%A Fong, J 
%T Synthesis of Analogs of <sc>GABA</sc> .15. Preparation and Resolution of Some Potent Cyclopentene and Cyclopentane Derivatives
%J Australian Journal of Chemistry
%D 1986/06/01
%V 39
%N 6
%P 855-864
%K 
%R https://doi.org/10.1071/CH9860855
%U https://www.publish.csiro.au/paper/CH9860855 
%X A series of cyclopentene and cyclopentane analogues of GABA has been prepared utilizing a thermal cis -trans isomerization of the phthalimido &#946;,&#947; -unsaturated acid (10) as the key step to obtain trans-4- aminocyclopent-2-ene-1-carboxylic acid (7). Resolution of some of the potent GABA analogues, in particular (+)-(4S)- and (-)-(4R)-4- aminocyclopent-1-ene-1-carboxylic acid (5), has been achieved by crystallization of isopropylideneribonolactone esters or pantolactone esters of the phthalimido -protected intermediates. 
