
%0 Journal Article
%A Capon, RJ 
%A Macleod, JK 
%T Two Epimeric Dibromo Nitriles From the Australian Sponge <I>Aplysina laevis</I>
%J Australian Journal of Chemistry
%D 1987/02/01
%V 40
%N 2
%P 341-346
%K 
%R https://doi.org/10.1071/CH9870341
%U https://www.publish.csiro.au/paper/CH9870341 
%X Two dibromo nitriles, (1&#8242;R,5&#8242;S,6&#8242;S)-2-(3&#8242;,5&#8242;-dibromo-1&#8242;,6&#8242;-dihydroxy-4&#8242;-oxocyclohex-2&#8242;- enyl) acetonitrile (5) and the (l&#8242;R,5&#8242;R,6&#8242;S) epimer (6), possessing antimicrobial activity, have been isolated from the sponge Aplysina  laevis  (Carter). Cometabolites (+)-aeroplysinin-1 (1) and the dibromo ketone (2) were also identified. Structures (5) and (6) were assigned on the basis of spectroscopic evidence and synthesis from (1). 
