
TY  - JOUR
A1  - Rickards, RW 
A1  - Rukachaisirikul, V 
T1  - 3-Amino-5-Hydroxybenzoic Acid in Antibiotic Biosynthesis. IX. The Status of Reduced Derivatives in Mitomycin Biosynthesis
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1987
VL  - 40
IS  - 5
SP  - 1011
EP  - 1015
KW  - 
UR  - https://doi.org/10.1071/CH9871011 
N2  - The addition of (methylene-2H2)-3-amino-5-hydroxybenzyl alcohol (8) hydrochloride to growing cultures of Streptomyces verticillatus inhibits production of the mitomycin antibiotic porfiromycin (2) by the microorganism. No incorporation of deuterium into porfiromycin occurs, and the isotopic composition of the alcohol recovered from the fermentation is unchanged. The significance of these results with regard to the immediate metabolic precursors of 3-amino-5-hydroxybenzoic acid (3) and the reduction stages involved in the established conversion of this amino acid into mitomycins are discussed. 
ER  -

