
%0 Journal Article
%A Barlin, GB 
%A Davies, LP 
%A Ngu, MML 
%T Imidazo[1,2-B]Pyridazines. III. Syntheses and Central Nervous-System Activities of Some 6-Chloro-3-methoxy (and ethoxy)-2-aryl (and heteroaryl)imidazo[1,2-B]pyridazines
%J Australian Journal of Chemistry
%D 1988/08/01
%V 41
%N 8
%P 1149-1156
%K 
%R https://doi.org/10.1071/CH9881149
%U https://www.publish.csiro.au/paper/CH9881149 
%X The synthesis of a series of 6-chloro-3-methoxy(and ethoxy )-2- phenyl[and (variously substituted phenyl), thienyl, and naphthalenyl ] imidazo [1,2-b] pyridazines and a 6-fluoro analogue are reported. These compounds were tested for their ability to displace [3H]diazepam bound to washed rat brain plasma membranes. Under standard assay conditions (see Experimental) and in the presence of 100 &#956;M &#947;- aminobutyric acid, 6-chloro-3-methoxy-2-(p-tolyl ) imidazo [1,2- b] pyridazine was the most active compound with an IC50 value of 148 nM (cf. diazepam, with IC50 of 4.2 nM). 
