
%0 Journal Article
%A Barlin, GB 
%A Ireland, SJ 
%T Potential Antimalarials.  VII. Di-Mannich Bases of 4-[(7'-Trifluoromethylquinolin-4'-yl)-Aminophenol and 4-(7'-Bromo-1',5'-naphthyridin-4'-yl)]-aminophenol via 4-Nitrophenols
%J Australian Journal of Chemistry
%D 1988/11/01
%V 41
%N 11
%P 1727-1733
%K 
%R https://doi.org/10.1071/CH9881727
%U https://www.publish.csiro.au/paper/CH9881727 
%X A series of di-Mannich bases have been prepared from 4-nitrophenol and paraformaldehyde with dimethylamine, diethylamine, dipropylamine, N- (2&#8242;-hydroxyethyl)methylamine, piperidine , 3- and 4-methylpiperidine, 3,5-dimethylpiperidine or pyrrolidine. These nitro compounds were reduced catalytically to the corresponding 4-aminophenols, which reacted with 4-chloro- 7-trifluoromethylquinoline and 7-bromo-4-chloro- 1,5-naphthyridine to give the required di-Mannich bases of 4-(7&#8242;- trifluoromethylquinolin-4&#8242;-yl)- and 4-(7&#8242;-bromo-1&#8242;,5&#8242;-naphthyridin-4&#8242;-yl)-aminophenol. 
