
%0 Journal Article
%A Donati, C 
%A Prager, RH 
%A Weber, B 
%T Potential GABA<sub>B</sub> Receptor Antagonists. III. Folded Baclofen Analogs Based on Phthalide
%J Australian Journal of Chemistry
%D 1989/06/01
%V 42
%N 6
%P 787-795
%K 
%R https://doi.org/10.1071/CH9890787
%U https://www.publish.csiro.au/paper/CH9890787 
%X Possible analogues of baclofen, 3-aminomethyl-5-chloro-, 3-aminomethyl-6-chloro- and 3-aminomethyl-5,6-dichloro-isobenzofuran-1(3H)-one, have been prepared for evaluation as antispasticity agents. The corresponding 3-hydroxyisobenzofuran-l(3H)-one was reacted with ethyl acetoacetate under acidic conditions, and the keto ester hydrolysed and decarboxylated to give the 3-(2-oxopropyl)isobenzofuran-l(3H)-one; this was treated with hydrazoic acid, and the product was hydrolysed. A parallel series of (3-oxo-1,3-dihydroisobenzofuran-1-y1)glycines was obtained by treating the keto ester first with hydrazoic acid, and hydrolysis of the resulting acetamides. 
