
%0 Journal Article
%A Deady, LW 
%A Ganakas, AM 
%A Ong, BH 
%T Ethoxycarbonylation of &#945;-Cyano-o-toluonitrile and Cyclization to Isoquinolines and Pyrimido[4,5-c]isoquinolines
%J Australian Journal of Chemistry
%D 1989/07/01
%V 42
%N 7
%P 1029-1034
%K 
%R https://doi.org/10.1071/CH9891029
%U https://www.publish.csiro.au/paper/CH9891029 
%X &#945; -Cyano-o-toluonitrile is a-ethoxycarbonylated with ethyl chloroformate and 4-dimethylamino- pyridine, and cyclized to ethyl 3-amino-1-bromoisoquinoline-4-carboxylate. This is further functionalized, and examples of third-ring annulation to pyrimido [4,5-c] isoquinolines are reported. 
