
%0 Journal Article
%A Donati, C 
%A Janowski, WK 
%A Prager, RH 
%A Taylor, MR 
%A Vilkins, LM 
%T Base Catalyzed Rearrangement of Isoxazolinyl Heterocycles: Synthesis of Annelated Pyrimidines
%J Australian Journal of Chemistry
%D 1989/12/01
%V 42
%N 12
%P 2161-2169
%K 
%R https://doi.org/10.1071/CH9892161
%U https://www.publish.csiro.au/paper/CH9892161 
%X The rearrangement of a number of ethyl 2-(heterocyclic)-5-oxo-2,5-dihydroisoxazole-4-carb-oxylates by mild base is described, leading to new syntheses of the pyrimido [2,1-a] isoquinoline, pyrimido [1,2-a]quinoline, pyrimido [2,1-b] benzothiazole , pyrirnido [1,2-a] pyrimidine, pyrimido [1,2-b]pyridazine and pyrimido [1,2-c] quinazoline ring systems. A mechanism is suggested, and X-ray crystallographic evidence presented for the structure of one of the products, ethyl 2-hydroxy-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate. 
