
TY  - JOUR
A1  - Donati, C 
A1  - Janowski, WK 
A1  - Prager, RH 
A1  - Taylor, MR 
A1  - Vilkins, LM 
T1  - Base Catalyzed Rearrangement of Isoxazolinyl Heterocycles: Synthesis of Annelated Pyrimidines
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1989
VL  - 42
IS  - 12
SP  - 2161
EP  - 2169
KW  - 
UR  - https://doi.org/10.1071/CH9892161 
N2  - The rearrangement of a number of ethyl 2-(heterocyclic)-5-oxo-2,5-dihydroisoxazole-4-carb-oxylates by mild base is described, leading to new syntheses of the pyrimido [2,1-a] isoquinoline, pyrimido [1,2-a]quinoline, pyrimido [2,1-b] benzothiazole , pyrirnido [1,2-a] pyrimidine, pyrimido [1,2-b]pyridazine and pyrimido [1,2-c] quinazoline ring systems. A mechanism is suggested, and X-ray crystallographic evidence presented for the structure of one of the products, ethyl 2-hydroxy-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate. 
ER  -

