
%0 Journal Article
%A Barlin, GB 
%A Yan, JH 
%T Potential Antimalarials. VIII. Mono- and Di-mannich Bases of 2-(7&#8242;-Trifluoro-methylquinolin-4&#8242;-ylamino)phenol Via 2-Nitrophenols
%J Australian Journal of Chemistry
%D 1989/12/01
%V 42
%N 12
%P 2191-2199
%K 
%R https://doi.org/10.1071/CH9892191
%U https://www.publish.csiro.au/paper/CH9892191 
%X Di-Mannich bases have been prepared by the reaction of 2-nitrophenol and formaldehyde with dimethylamine, diethylamine, dipropylamine, pyrrolidine, piperidine, 2-, 3- and 4-methylpiperidine, 3,5-dimethylpiperidine and morpholine. The nitro compounds were reduced catalytically to the corresponding 2-aminophenols which with 4-chloro-7-trifluoromethylquinoline gave the di-Mannich bases of 2-(7&#8242;-trifluoromethylquinolin-4&#8242;-ylamino)phenol. Analogous compounds were synthesized from 3-and 5-methyl-2-nitrophenols, and pyrrolidine. The mono-Mannich compounds, 6-(3&#8242;-methylpiperidin-1&#8242;-ylmethyl)- and 6-(pyrrolidin-1&#8242;- ylmethyl)-2-(7&#8243;-trifluoromethylquinolin-4&#8243;-ylamino)pheno, were also prepared. The results for tests against a chloroquine-sensitive isolate (FCQ-27) and chloroquine-resistant isolate (K-1) of Plasmodium falciparum are reported. 
