
TY  - JOUR
A1  - Barlin, GB 
A1  - Yan, JH 
T1  - Potential Antimalarials. VIII. Mono- and Di-mannich Bases of 2-(7&#8242;-Trifluoro-methylquinolin-4&#8242;-ylamino)phenol Via 2-Nitrophenols
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1989
VL  - 42
IS  - 12
SP  - 2191
EP  - 2199
KW  - 
UR  - https://doi.org/10.1071/CH9892191 
N2  - Di-Mannich bases have been prepared by the reaction of 2-nitrophenol and formaldehyde with dimethylamine, diethylamine, dipropylamine, pyrrolidine, piperidine, 2-, 3- and 4-methylpiperidine, 3,5-dimethylpiperidine and morpholine. The nitro compounds were reduced catalytically to the corresponding 2-aminophenols which with 4-chloro-7-trifluoromethylquinoline gave the di-Mannich bases of 2-(7&#8242;-trifluoromethylquinolin-4&#8242;-ylamino)phenol. Analogous compounds were synthesized from 3-and 5-methyl-2-nitrophenols, and pyrrolidine. The mono-Mannich compounds, 6-(3&#8242;-methylpiperidin-1&#8242;-ylmethyl)- and 6-(pyrrolidin-1&#8242;- ylmethyl)-2-(7&#8243;-trifluoromethylquinolin-4&#8243;-ylamino)pheno, were also prepared. The results for tests against a chloroquine-sensitive isolate (FCQ-27) and chloroquine-resistant isolate (K-1) of Plasmodium falciparum are reported. 
ER  -

