
TY  - JOUR
A1  - Rizzacasa, MA 
A1  - Sargent, MV 
A1  - Skelton, BW 
A1  - White, AH 
T1  - The Stereoisomers of 5-Bromo-6,8-dimethoxy-1,2,3-trimethyl-1,2,3,4-tetrahydroisoquinoline. X-Ray Crystal-Structure of the <I>trans</I> Isomer
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1990
VL  - 43
IS  - 1
SP  - 79
EP  - 86
KW  - 
UR  - https://doi.org/10.1071/CH9900079 
N2  - Henry reaction between 3,5-dimethoxybenzaldehyde (2) and nitroethane gave (E)-2-(3,5-dimethoxyphenyl)-1-methyl-1-nitroethene (3). Under mild conditions the erythro and threo nitro aldols intermediate in this reaction could be isolated as their acetates. The threo isomer was obtained in diastereoisomeric excess. The nitrostyrene (3) was converted in several steps into cis-(20) and trans-5-bromo-6,8-dimethoxy-1,2,3-trimethyl-1,2,3,4-tetrahydroisoquinoline (18). The single-crystal X-ray structure of compound (18) is reported. 
ER  -

