
%0 Journal Article
%A Barlin, GB 
%A Davies, LP 
%A Ireland, SJ 
%A Khoo, CLY 
%A Nguyen, TMT 
%T Imidazo[1,2-B]pyridazines. IX. Syntheses and Central Nervous System Activities of Some 3-Alkoxy-6-(o-alkoxy, o-methylthio- or o-fluoro-phenoxy)-2-arylimidazo[1,2-b]pyridazines
%J Australian Journal of Chemistry
%D 1990/03/01
%V 43
%N 3
%P 503-510
%K 
%R https://doi.org/10.1071/CH9900503
%U https://www.publish.csiro.au/paper/CH9900503 
%X Syntheses are reported for a series of 6-(o-methoxy -, o-ethoxy -, o-methylthio - and o-fluoro-phenoxy )-3-( methoxy and ethoxy )-2- phenyl(substituted phenyl and pyridin-3&#8243;-yl) imidazo [1,2-b] pyridazines . IC50 values are reported for the displacement of 3H-diazepam from rat brain membrane by each of these compounds. The most active compounds were found to be 3-ethoxy-2-(p- fluorophenyl )-6-(o- methoxyphenoxy )-, 3-methoxy-6-(o- methoxyphenoxy )-2-(m-nitrophenyl )- and 3-methoxy-6-(o- methoxyphenoxy )-2-(3&#8243;,4&#8243;-methylenedioxy ) imidazo [1,2-b] pyridazines with IC5O values of 15, 18 and 19 nM respectively. 
