
%0 Journal Article
%A Moloney, GP 
%A Craik, DJ 
%A Iskander, MN 
%A Munro, SLA 
%T <sup>1</sup>H-N.M.R. and Theoretical Studies of the Conformation of the Antibiotic Lincomycin
%J Australian Journal of Chemistry
%D 1990/03/01
%V 43
%N 3
%P 535-548
%K 
%R https://doi.org/10.1071/CH9900535
%U https://www.publish.csiro.au/paper/CH9900535 
%X One- and two-dimensional 1H n.m.r. spectra of the amino glycoside antibiotic lincomycin have been measured and analysed. One-dimensional n.m.r. techniques applied included selective decoupling, resolution enhancement, and n.O.e. difference experiments. Two-dimensional n.m.r. techniques included chemical shift correlated spectroscopy (COSY) and n.O.e. spectroscopy (NOESY) experiments. A theoretical conformational analysis of the side chain of the sugar moiety has also been done by using a simplified potential energy program. Together, the theoretical and experimental (coupling constant and n.O.e.) data have allowed the conformation of lincomycin to be determined. 
