
%0 Journal Article
%A Bray, AM 
%A Kelly, DP 
%A Mack, POL 
%A Martin, RF 
%A Wakelin, LPG 
%T DNA-Binding Compounds. III. Synthesis of a Peptide-Linked Binuclear Platinum(II)-Terpyridine Complex
%J Australian Journal of Chemistry
%D 1990/03/01
%V 43
%N 3
%P 629-634
%K 
%R https://doi.org/10.1071/CH9900629
%U https://www.publish.csiro.au/paper/CH9900629 
%X A procedure has been developed for linking two terpyridineplatinum(II), Pt(tpy), chromophores by an oligopeptide chain. It relies on the use of a new reagent, succinimido 3- (triphenylmethylthio)propanoate (2), to acylate the amino end groups of an &#945;,&#969;-diaminoalkane peptide. Subsequent deprotection of the sulfhydryl groups and coupling with [ (tpy )PtlICl ]CI yields the binuclear complexes in good yields. This procedure allowed the synthesis of [ ( tpy )PtS(CH2)2 CO-Gly-Gly-Gly-NH(CH2)3NHCO-(CH2)2SPt(tpy)Cl2 (5b). 
