
TY  - JOUR
A1  - Bray, AM 
A1  - Kelly, DP 
A1  - Mack, POL 
A1  - Martin, RF 
A1  - Wakelin, LPG 
T1  - DNA-Binding Compounds. III. Synthesis of a Peptide-Linked Binuclear Platinum(II)-Terpyridine Complex
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1990
VL  - 43
IS  - 3
SP  - 629
EP  - 634
KW  - 
UR  - https://doi.org/10.1071/CH9900629 
N2  - A procedure has been developed for linking two terpyridineplatinum(II), Pt(tpy), chromophores by an oligopeptide chain. It relies on the use of a new reagent, succinimido 3- (triphenylmethylthio)propanoate (2), to acylate the amino end groups of an &#945;,&#969;-diaminoalkane peptide. Subsequent deprotection of the sulfhydryl groups and coupling with [ (tpy )PtlICl ]CI yields the binuclear complexes in good yields. This procedure allowed the synthesis of [ ( tpy )PtS(CH2)2 CO-Gly-Gly-Gly-NH(CH2)3NHCO-(CH2)2SPt(tpy)Cl2 (5b). 
ER  -

