
%0 Journal Article
%A Evans, RF 
%A Savage, GP 
%A Gough, DA 
%T The Synthesis of 4(6)-t-Butylpyrimidines From 4(6)-Halopyrimidines by Using Higher-Order Lithium and Magnesium Organocuprate Reagents
%J Australian Journal of Chemistry
%D 1990/04/01
%V 43
%N 4
%P 733-740
%K 
%R https://doi.org/10.1071/CH9900733
%U https://www.publish.csiro.au/paper/CH9900733 
%X t-Butyllithium and t- butylmagnesium chloride cyanocuprates were used to prepare 4(6)-t- butylpyrimidines from the corresponding 4(6)-halopyrimidines . The highly hindered 2,4,5-tri-t-butyl-6-chloropyrimidine, containing an ortho-di-t-butyl arrangement, was prepared by this method. No alkyl group isomerization was observed but some substrate reduction was detected. 
