
%0 Journal Article
%A Chi, WO 
%A Hong, CL 
%T A Rapid Synthesis of 2,3,11,11a-Tetrahydro-6H-pyrazino[1,2-b]isoquinoline-1,4-diones Through an Amido Iminium Ion Cyclization
%J Australian Journal of Chemistry
%D 1990/04/01
%V 43
%N 4
%P 773-775
%K 
%R https://doi.org/10.1071/CH9900773
%U https://www.publish.csiro.au/paper/CH9900773 
%X 7,10-Dimethoxy-6-methyl-2,3,11,11a-tetrahydro-6H-pyrazino[1,2-b]isoquinoline-1,4-diones (5) and (6) were synthesized from glycine anhydride and 2,5-dimethoxybenzaldehyde through an amido iminium ion cyclization reaction. This method for the construction of the tetrahydroisoquinoline ring will be useful for the synthesis of saframycins. 
