
%0 Journal Article
%A Barlin, GB 
%A Jiravinyu, C 
%T Potential Antimalarials. X. Di-Mannich Bases of 4-(7'-Trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol and N-(4'-Diethylamino-1'-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4- amine
%J Australian Journal of Chemistry
%D 1990/07/01
%V 43
%N 7
%P 1175-1181
%K 
%R https://doi.org/10.1071/CH9901175
%U https://www.publish.csiro.au/paper/CH9901175 
%X The syntheses of some di-Mannich bases derived from 4-(7&#8242;-trifluoromethyl-1&#8242;,5&#8242;-naphthyridin-4&#8242;-ylamino) phenol and of N-(4&#8242;-diethylamino-11&#8242;-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4- amine from 3-chloro-5-trifluoromethylpyridine via4-chloro-7- trifluoromethyl-1,5-naphthyridine are described. In tests in vitro against the FCQ-27 strain of Plasmodium falciparum these compounds were slightly less active than their 7-bromo analogues. 
