
TY  - JOUR
A1  - Allan, RD 
A1  - Apostopoulos, C 
T1  - Synthesis of Substituted (+)-Bicuculline Derivatives Through Chloromethylation
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1990
VL  - 43
IS  - 7
SP  - 1259
EP  - 1268
KW  - 
UR  - https://doi.org/10.1071/CH9901259 
N2  - Treatment of the phthalide  isoquinoline alkaloid (+)- bicuculline with paraformaldehyde and hydrochloric acid leads to the chloromethyl derivative (4) which can be further substituted with ammonia or piperazine . In reactions to study methods of linking bicuculline to macromolecules or to photolabile groups, the amino product (7a) has been further functionalized by the formation of amide linkages with succinic anhydride and 4-aminobenzoic acid. 
ER  -

