
%0 Journal Article
%A Barlin, GB 
%A Jiravinyu, C 
%T Potential Antimalarials. XII. 4-Chloro-3-(substituted amino)methyl-5-[7-bromo (and 7-trifluoromethyl)-1,5-naphthyridin-4-ylamino]biphenyl-2-ols and 4-Chloro-3-(substituted amino)methyl-5-(7-trifluoromethyl-quinazolin-4-ylamino)biphenyl-2-ols
%J Australian Journal of Chemistry
%D 1990/08/01
%V 43
%N 8
%P 1367-1373
%K 
%R https://doi.org/10.1071/CH9901367
%U https://www.publish.csiro.au/paper/CH9901367 
%X The mono- Mannich bases 3-(t- butylamino )methyl-4?-chloro-, 3-(4- benzylpiperidin-1-yl)methyl-4&#8242;-chloro-, 3-(4-benzylpiperazin-1- yl )methyl-4&#8242;-chloro-, 4&#8242;-chloro-3-diethylaminomethyl-, 4&#8242;-chloro-3-(pyrrolidin-1-yl)methyl-, 4&#8242;-chloro-3-(piperidin-1-yl)methyl- and 4&#8242;-chloro-3-(3- and 4- methylpiperidin-1-yl)methyl-5-[7-bromo (and 7- trifluoromethyl )-1,5-naphthyridin-4-ylamino]- biphenyl-2-ol, and the corresponding substituted 5-(7-trifluoromethylquinazolin-4-ylamino)bi- phenyl-2-ols, have been prepared by condensation of the 5-amino-3-(N- substituted aminomethyl )-4&#8242;-chlorobiphenyl-2-ols and the appropriate 4-chloro  heterocycle. The antimalarial activity of these products against the chloroquine-sensitive isolate (FCQ-27) of Plasmodium falciparum revealed that the 1,5-naphthyridines reported here were less active than the corresponding di-Mannich bases, e.g. (6), derived from 4-[7- bromo (and 7-trifluoromethyl)-1?,5&#8242;-naphthyridin-4&#8242;-ylamino]phenol, a feature not shared by the corresponding quinazolines. 
