
%0 Journal Article
%A Halladay, PK 
%A Cowden, WB 
%T 3-Methyl-8-(substituted phenyl)-pteridine-2,4(3H,8H)-diones as Potential Antimalarials
%J Australian Journal of Chemistry
%D 1990/08/01
%V 43
%N 8
%P 1449-1454
%K 
%R https://doi.org/10.1071/CH9901449
%U https://www.publish.csiro.au/paper/CH9901449 
%X A series of 6,7,8-substituted 3-methylpteridine-2,4(3H,8H)- diones was synthesized by condensation of 5-amino-6-(substituted anilino )-3-methylpyrimidine-2,4(1H,3H)- dione with &#945;- dicarbonyl reagents. These compounds were tested for antimalarial activity against the human parasite Plasmodium falciparum in culture, and lethal Plasmodium vinckei vinckei in mice. The 6,7-unsubstituted pteridinediones were active against cultured P. Falciparum ; however, none of the series was active against P. vinckei vinckei in mice. 
