
TY  - JOUR
A1  - Halladay, PK 
A1  - Cowden, WB 
T1  - 3-Methyl-8-(substituted phenyl)-pteridine-2,4(3H,8H)-diones as Potential Antimalarials
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1990
VL  - 43
IS  - 8
SP  - 1449
EP  - 1454
KW  - 
UR  - https://doi.org/10.1071/CH9901449 
N2  - A series of 6,7,8-substituted 3-methylpteridine-2,4(3H,8H)- diones was synthesized by condensation of 5-amino-6-(substituted anilino )-3-methylpyrimidine-2,4(1H,3H)- dione with &#945;- dicarbonyl reagents. These compounds were tested for antimalarial activity against the human parasite Plasmodium falciparum in culture, and lethal Plasmodium vinckei vinckei in mice. The 6,7-unsubstituted pteridinediones were active against cultured P. Falciparum ; however, none of the series was active against P. vinckei vinckei in mice. 
ER  -

