
TY  - JOUR
A1  - Cherubim, P 
A1  - Deady, LW 
T1  - Nucleophilic Substitution Reactions in Benzo[C][1,8]naphthyridines. II.
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1990
VL  - 43
IS  - 8
SP  - 1469
EP  - 1473
KW  - 
UR  - https://doi.org/10.1071/CH9901469 
N2  - 3-Chloro-1-methyl-6-(p- methylphenoxy ) benzo [c][1,8] naphthyridine has been prepared, the reactions with various nitrogen, oxygen and sulfur nucleophiles studied, and the results compared with those for the 1- chloro-3-methyl isomer. The 6-position was more reactive for oxygen and nitrogen nucleophiles, so much so that an initially added 6-NHR group was displaced by a second R&#8242;NH2 nucleophile at least as readily as was the 3-chloro group. With p- chloro ( thiophenol ), however, the 3-chloro group was preferentially displaced. 
ER  -

