
%0 Journal Article
%A McCluskey, Adam 
%A Finn, Matthew 
%A Bowman, Maria 
%A Smith, Roger 
%A Keller, Paul A. 
%T 2,7-Dimethylthiazolo[4,5-<emph type="2">d</emph>]pyradazine-4-(5<emph type="2">H</emph>)-thione: A Corticotrophin-Releasing Hormone Type 1 Receptor Agonist
%J Australian Journal of Chemistry
%D 2001/05/11
%V 53
%N 12
%P 905-908
%K Thiazoles; agonist; CRH; &#946;-endorphin.
%R https://doi.org/10.1071/CH99015
%U https://www.publish.csiro.au/paper/CH99015 
%X Thiazoles, including 2,7-dimethylthiazolo&#91;4,5-d&#93;pyradazine-4-(5H)-thione (4b) and the corresponding 5-phenylthiazolo&#91;4,5-d&#93;pyradazine-4-methylthiol (5a), were synthesized as part of an ongoing investigation into corticotrophin-releasing hormone (CRH) type 1 receptor activity. Subsequent screening indicated the successful discovery of receptor agonists. Assay results indicated a 52 and 3% increase in &#946;-endorphin release after the administration of 100 M (4b) and (5a), respectively. It is believed that this represents the first evidence of this class of compounds displaying CRH type 1 receptor agonist activity. 
