
TY  - JOUR
A1  - McCluskey, Adam 
A1  - Finn, Matthew 
A1  - Bowman, Maria 
A1  - Smith, Roger 
A1  - Keller, Paul A. 
T1  - 2,7-Dimethylthiazolo[4,5-<emph type="2">d</emph>]pyradazine-4-(5<emph type="2">H</emph>)-thione: A Corticotrophin-Releasing Hormone Type 1 Receptor Agonist
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2001
VL  - 53
IS  - 12
SP  - 905
EP  - 908
KW  - Thiazoles; agonist; CRH; &#946;-endorphin.
UR  - https://doi.org/10.1071/CH99015 
N2  - Thiazoles, including 2,7-dimethylthiazolo&#91;4,5-d&#93;pyradazine-4-(5H)-thione (4b) and the corresponding 5-phenylthiazolo&#91;4,5-d&#93;pyradazine-4-methylthiol (5a), were synthesized as part of an ongoing investigation into corticotrophin-releasing hormone (CRH) type 1 receptor activity. Subsequent screening indicated the successful discovery of receptor agonists. Assay results indicated a 52 and 3% increase in &#946;-endorphin release after the administration of 100 M (4b) and (5a), respectively. It is believed that this represents the first evidence of this class of compounds displaying CRH type 1 receptor agonist activity. 
ER  -

