
%0 Journal Article
%A Perich, JW 
%A Johns, RB 
%T Synthesis of Casein-Related Peptides and Phosphopeptides. V. The Efficient Global 'Phosphite-Triester' Phosphorylation of Protected Serine Derivatives and Peptides by Using Dibenzyl or Di-t-butyl N,N-Diethylphosphoramidite
%J Australian Journal of Chemistry
%D 1990/10/01
%V 43
%N 10
%P 1623-1632
%K 
%R https://doi.org/10.1071/CH9901623
%U https://www.publish.csiro.au/paper/CH9901623 
%X Both dibenzyl N,N- diethylphosphoramidite and di -t-butyl N,N- diethylphosphoramidite are shown to be suitable reagents for the efficient 1H-tetrazole-catalysed 'phosphite-triester' phosphorylation of the protected serine derivative Boc-Ser-OCH2C6H4NO2-p. Both these reagents were also used for the phosphorylation of the protected serine derivative Boc-Glu ( OBut )-Ser- Leu-OBut, and subsequent hydrogenolytic treatment of Boc-Glu ( OBut )-Ser(PO3Bzl2)- Leu-OBut or acidolytic treatment of Boc-Glu ( OBut )-Ser(PO3But2)- Leu-OBut gave the O- phosphoseryl tripeptide Glu -Ser(PO3H2)- Leu in near-quantitive yield. 
