
%0 Journal Article
%A Barlin, GB 
%A Jiravinyu, C 
%T Potential Antimalarials. XIII. Mono-Mannich Bases of 4-[7-Chloro (and 7-trifluoromethyl)quinolin-4-ylamino] and 4-(7-Bromo-1,5-naphthyridin-4-ylamino)-3-methylphenol
%J Australian Journal of Chemistry
%D 1991/01/01
%V 44
%N 1
%P 151-156
%K 
%R https://doi.org/10.1071/CH9910151
%U https://www.publish.csiro.au/paper/CH9910151 
%X The preparation of di-Mannich bases derived from 4-[7-chloro(and 7-trifluoromethyl)quinolin-4-ylamino] and 4-(7-bromo-1,5-naphthyridin-4-ylamino)-3-methylphenol are reported.  In tests for antimalarial activity against the FCQ-27 ( chloroquine -sensitive) and K-1 ( chloroquine -resistant) isolates of Plasmodium falciparum in vitro, the 3-methylphenols were shown to be less active than their demethyl analogues reported previously. 
