
TY  - JOUR
A1  - Perich, JW 
A1  - Alewood, PF 
A1  - Johns, RB 
T1  - Synthesis of Casein-Related Peptides and Phosphopeptides. VIII. The Synthesis of Ser(P)-Containing Peptides by the Use of Z-Ser(PO<sub>3</sub>R<sub>2</sub>)-OH Derivatives
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1991
VL  - 44
IS  - 2
SP  - 253
EP  - 263
KW  - 
UR  - https://doi.org/10.1071/CH9910253 
N2  - .The synthesis of five Z-Ser(PO3R2)-OH (R = phenyl, ethyl, methyl, benzyl, t-butyl) derivatives is described by a simple three-step synthetic procedure which features the use of either (A) diphenyl or dialkyl  phosphorochloridate /pyridine or (B) dialkyl N,N-diethylphosphoramidite/1H-tetrazole-m-chloroperoxybenzoic acid for the phosphorylation of the serine hydroxy group. The benzyl phosphate derivative, Z-Ser(PO3Bzl2)-OH, was used in the benzyloxycarbonyl mode of peptide synthesis for the preparation of Z-Ser(PO3Bzl2)-Leu-OBzl and Z-Ser(PO3Bzl2)-Ser(PO3Bzl2)- OBzl which were deprotected by palladium- catalysed  hydrogenolysis to give Ser(P)-Leu and Ser(P)-Ser(P) in high yields and high purity. 
ER  -

