
%0 Journal Article
%A Prager, RH 
%A Tsopelas, C 
%A Heisler, T 
%T A Simple Synthesis of Amphimedine
%J Australian Journal of Chemistry
%D 1991/02/01
%V 44
%N 2
%P 277-285
%K 
%R https://doi.org/10.1071/CH9910277
%U https://www.publish.csiro.au/paper/CH9910277 
%X The marine alkaloid amphimedine has been synthesized by a short sequence of reactions commencing from the known indenopyridinedione (2). Reaction with 4-pyridyllithium, followed by hydrazoic acid treatment, gave 5-(4-pyridyl)-3,6-phenanthrolin-4(3H)-one (12) which was converted into the chlorophenanthroline. The methyl-substituted fluorosulfonate salt of this compound was specifically oxidized by alkaline ferricyanide. Conversion of the pyridone into the nitrile gave the precursor which was cyclized to amphimedine by polyphosphoric acid. 
