
%0 Journal Article
%A Grant, PK 
%A Hanton, LR 
%A Tsai, SF 
%A Yap, TM 
%T Intramolecular Participation Reactions in Labda-8(17),14-dien-13-ol (Manool) Derivatives
%J Australian Journal of Chemistry
%D 1991/03/01
%V 44
%N 3
%P 433-446
%K 
%R https://doi.org/10.1071/CH9910433
%U https://www.publish.csiro.au/paper/CH9910433 
%X Lewis acid treatment of a series of hydroxy  epoxides promoted intramolecular  nucleophilic epoxide opening to give hydroxy cyclic ethers. The regioselectivity of epoxide opening is controlled by a preference for SN2 attack at the more accessible epoxide carbon, provided this does not involve the formation of a strained ether ring. An intramolecular acetate transfer occurs in order to achieve the regioselective opening. 
