
TY  - JOUR
A1  - Banwell, MG 
A1  - Cameron, JM 
A1  - Collis, MP 
A1  - Crisp, GT 
A1  - Gable, RW 
A1  - Hamel, E 
A1  - Lambert, JN 
A1  - Mackay, MF 
A1  - Reum, ME 
A1  - Scoble, JA 
T1  - The Palladium-Mediated Cross Coupling of Bromotropolones With Organostannanes or Arylboronic Acids: Applications to the Synthesis of Natural Products and Natural Product Analogs
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1991
VL  - 44
IS  - 5
SP  - 705
EP  - 728
KW  - 
UR  - https://doi.org/10.1071/CH9910705 
N2  - The bromotropolones (4), (5) and (10) undergo palladium-mediated cross coupling with a wide range of organostannanes to produce alkenyl -, alkyl- and aryl-substituted tropolones . The methodology has been applied to the synthesis of the monoterpenes &#946;- dolabrin (11),&#946;- thujaplicin (12), 4-isopropyl-7-methoxytropolone (13) and &#946;- thujaplicinol (14). Cross coupling of bromotropolones (4), (5) and (10) with various aryltrimethylstannanes or arylboronic acids has permitted the preparation of the bicyclic colchicine analogues (30)-(43) which have been tested for tubulin -binding activity. The X-ray crystal structure of the most active of these systems, compound (38), is reported. 
ER  -

