
TY  - JOUR
A1  - Quinn, RJ 
A1  - Scammells, PJ 
A1  - Tucker, DJ 
T1  - Mono-&#945;-carbamoylethylthio-Substituted Pyrazolo[3,4-d]pyrimidines: the Position of Substitution
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1991
VL  - 44
IS  - 5
SP  - 753
EP  - 757
KW  - 
UR  - https://doi.org/10.1071/CH9910753 
N2  - Pyrazolo [3,4-d] pyrimidines are a general class of compounds which exhibit adenosine receptor affinity. One particular compound, &#945;-{6-(1&#945;-carbamoylethylthio)-1-phenylpyrazolo-[3,4-d]pyrimidin-4-ylthio} propionamide (1a), has been shown to have antagonist activity an order of magnitude greater than theophylline at the A1 adenosine receptor. The synthesis, structural elucidation by n.m.r. spectroscopy, and adenosine receptor affinity of the mono-&#945;- carbamoylethylthio analogue is now reported. 
ER  -

