
%0 Journal Article
%A Arbain, D 
%A Langley, J 
%A Picker, K 
%A Taylor, WC 
%T The Determination of Chirality of N-Methyl- and N,N-Dimethyl-phenylalanine by G.L.C.
%J Australian Journal of Chemistry
%D 1991/06/01
%V 44
%N 6
%P 887-890
%K 
%R https://doi.org/10.1071/CH9910887
%U https://www.publish.csiro.au/paper/CH9910887 
%X The chirality of N- methylphenylalanine enantiomers can be determined on a micro scale by g.l.c . of N-pentafluoropropionyl amino acid isopropyl esters on a Chirasil -L-Val capillary column. N,N- Dimethylphenylalanine enantiomers cannot be similarly derivatized and cannot be separated. However, prior treatment with ethyl chloroformate followed by acid hydrolysis effects demethylation to the N-methyl analogues which can then be derivatized for g.l.c . Contrary to literature reports N-methylphenylalanine can be prepared by reductive alkylation of phenylalanine. 
