
TY  - JOUR
A1  - Lawrance, GA 
A1  - Maeder, M 
A1  - Oleary, MA 
A1  - Skelton, BW 
A1  - White, AH 
T1  - Macrocycle Formation From Copper(II)Directed Condensation of Linear Tetraamines With Formaldehyde Alone and With Added 2-Aminoethanol
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1991
VL  - 44
IS  - 9
SP  - 1227
EP  - 1236
KW  - 
UR  - https://doi.org/10.1071/CH9911227 
N2  - Reaction of several tetraaminecopper(II) complexes with paraformaldehyde in acetonitrile or dioxan yields oxatetraazacycloalkanecopper(II) complexes, with a new -NH-CH2-O-CH2-NH-link completing the cyclization. The complexes are stable in aqueous acid for appreciable lengths of time, but eventually decompose, with the precursor tetraaminecopper(II) the major product. In alcohol with aqueous formaldehyde, the products are not detected. However, aqueous formaldehyde reacts with a methanolic solution of the copper(II) complex of 4,7- diazadecane-1,10-diamine in the presence of added 2-aminoethanol to produce the polycyclic polyamino ether complex (3-oxa-1,6,8,12,15-pentaazatricyclo[13.3.1.1.8,12]icosane)copper(II) perchlorate. This complex crystallized in the monoclinic space group C2/c, a 32.777(8), b 9.395(2), c 14.914(6)&#506;, &#946; 111.97(2)&#176;. The structure identifies three -NH-CH2-NH- links, two as parts of new diazacyclohexane rings, and a single -O-CH2-NH- link, all arising from condensation of the polyamine and/or the amino alcohol with formaldehyde. The copper ion lies in a plane of three nitrogens [Cu-N 1.976(4), 2.012(4) and 2.020(3)&#506;] and the ether oxygen [Cu-O 2.008(3)&#506;]. 
ER  -

