
%0 Journal Article
%A Bray, AM 
%A Kelly, DP 
%A Lim, TK 
%T Dna-Binding Compounds. IV. Synthesis and Solution Conformation of a Novel Macrocyle Formed by Coupling of the Side-Chains of Adjacent L-Lysine Residues
%J Australian Journal of Chemistry
%D 1991/11/01
%V 44
%N 11
%P 1649-1658
%K 
%R https://doi.org/10.1071/CH9911649
%U https://www.publish.csiro.au/paper/CH9911649 
%X The novel macrocyclic  dilysine derivatives (8S,11S)-11-t-butoxycarbonylamino-2,10-dioxo-1,3,9-triazacyclopentadecane-8-carboxylic acid methyl (5) and t-butyl (6) esters were prepared by coupling of the &#1108;-amino groups of adjacent lysine residues of the esters of Boc-Lys-Lys-OR with 1,1&#8242;-carbonyldiimidazole under mild conditions. The conformation of (6) in dimethyl sulfoxide solution was determined by the use of a variety of one- and two-dimensional n.m.r. techniques. 
