
TY  - JOUR
A1  - McPhee, Meredith E. 
A1  - Katsifis, Andrew G. 
A1  - Mattner, Filomena 
A1  - Ridley, Damon D. 
T1  - Synthesis of <emph type="7">123</emph>I-Labelled Analogues of Imidazobenzodiazepine Receptor Ligands.
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2000
VL  - 52
IS  - 11
SP  - 1061
EP  - 1070
KW  - 
UR  - https://doi.org/10.1071/CH99135 
N2  - Reaction of bromo- or iodo-substituted isatoic anhydrides with N-methylglycine, L-proline or D-proline afforded bromo- or iodo-substituted 1,4-benzodiazepinediones which on condensation with ethyl or t-butyl isocyanoacetates gave ethyl or t-butyl bromo- or iodo-imidazobenzodiazepine carboxylates. These aryl halides were converted into the corresponding tributylstannanes with bis(tributyltin) in the presence of (triphenylphosphine)palladium(0), and the stannanes were treated with sodium (123I)iodide in the presence of chloramine-Tto give the required 123I- labelled analogues of the imidazobenzodiazepine receptor ligands flumazenil and bretazenil. 
ER  -

