
TY  - JOUR
A1  - Bu, Xianyong 
A1  - Deady, Leslie W. 
A1  - Denny, William A. 
T1  - Synthesis and Cytotoxic Activity of <emph type="2">N</emph>-[2-(Dimethylamino)ethyl] Carboxamide Derivatives of Benzofuro[2,3-<emph type="2">b</emph>]quinoline, 6<emph type="2">H</emph>-Quinindoline, Indeno[2,1-<emph type="2">b</emph>]quinoline and [1]Benzothieno[2,3-<emph type="2">b</emph>]quinoline
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 2000
VL  - 53
IS  - 2
SP  - 143
EP  - 147
KW  - Antitumour; cytotoxic; synthesis; carboxamides; quinoline.
UR  - https://doi.org/10.1071/CH99166 
N2  - The acid precursors of the title compounds were prepared from methyl 2-amino-3-formylbenzoate (3), by Friedl&#196;nder synthesis with o-methoxy- and o-nitro-phenylacetic acids, phenylpyruvic acid and benzo&#91;b&#93;thiophen-2-one, respectively. Except for the last example, cyclization of an initial 3-arylquinoline derivative was then required to give the tetracycle. Growth inhibition properties of the carboxamides in a series of cancer cell lines were measured for comparison with previous data for an isomeric series. In all cases, the present set were found to be less active. 
ER  -

