
%0 Journal Article
%A Camp, D 
%A Jenkins, ID 
%T The Mechanism of the Mitsunobu Reaction. III. The Use of Tributylphosphine
%J Australian Journal of Chemistry
%D 1992/01/01
%V 45
%N 1
%P 47-55
%K 
%R https://doi.org/10.1071/CH9920047
%U https://www.publish.csiro.au/paper/CH9920047 
%X 31P n.m.r . studies indicate that, when tributylphosphine is used in the Mitsunobu  esterification reaction, clean formation of a single intermediate, an alkoxyphosphonium carboxylate, is apparent. In the absence of acid, at least two species are observed, a dialkoxytributylphoshorane and the corresponding alkoxyphosphonium salt. The order of mixing of the reagents can dramatically change the mechanism and stereochemistry of esterification reactions. 
