
TY  - JOUR
A1  - Evans, RF 
A1  - Savage, GP 
T1  - Methylation of Some Deprotonated Sterically Hindered Pyrimidin-4-ols
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1992
VL  - 45
IS  - 2
SP  - 463
EP  - 468
KW  - 
UR  - https://doi.org/10.1071/CH9920463 
N2  - Anions derived from t-butyl-substituted pyrimidin-4-ols were methylated with iodomethane . The site of methylation was determined by proton-coupled 13C n.m.r. and the relative proportions of isomers were determined by 1H n.m.r. A t-butyl substituent  ortho to a ring nitrogen markedly reduced the propensity for methylation at that nitrogen to the point where O-methylation, uncommon under these conditions, was observed. 
ER  -

