
%0 Journal Article
%A Abbenante, G 
%A Prager, RH 
%T Potential GABA<sub>B</sub> Receptor Antagonists. V. The Application of Radical Additions to Styrenes to Produce 2-Hydroxysaclofen
%J Australian Journal of Chemistry
%D 1992/11/01
%V 45
%N 11
%P 1791-1800
%K 
%R https://doi.org/10.1071/CH9921791
%U https://www.publish.csiro.au/paper/CH9921791 
%X 3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid (2-hydroxysaclofen), and its 2- phenyl analogue have been synthesized by three methods. Two involve the oxygen- catalysed free radical addition of bisulfite to the corresponding 3-aminopropene or 3-phthalimidopropene, and the third involves the sulfite opening of the epoxide of the phthalimidopropene. 2-Hydroxysaclofen is a potent antagonist of GABA and baclofen at the GABAB receptor site. 
