
TY  - JOUR
A1  - Abbenante, G 
A1  - Prager, RH 
T1  - Potential GABA<sub>B</sub> Receptor Antagonists. V. The Application of Radical Additions to Styrenes to Produce 2-Hydroxysaclofen
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1992
VL  - 45
IS  - 11
SP  - 1791
EP  - 1800
KW  - 
UR  - https://doi.org/10.1071/CH9921791 
N2  - 3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid (2-hydroxysaclofen), and its 2- phenyl analogue have been synthesized by three methods. Two involve the oxygen- catalysed free radical addition of bisulfite to the corresponding 3-aminopropene or 3-phthalimidopropene, and the third involves the sulfite opening of the epoxide of the phthalimidopropene. 2-Hydroxysaclofen is a potent antagonist of GABA and baclofen at the GABAB receptor site. 
ER  -

