
%0 Journal Article
%A Abbenante, G 
%A Prager, RH 
%T Potential GABA<sub>B</sub> Receptor Antagonists. VI. The Synthesis of Saclofen and Other Sulfonic Acid Derivatives
%J Australian Journal of Chemistry
%D 1992/11/01
%V 45
%N 11
%P 1801-1810
%K 
%R https://doi.org/10.1071/CH9921801
%U https://www.publish.csiro.au/paper/CH9921801 
%X Saclofen, 3-amino-2-(4chlorophenyl) propanesulfonic acid (3), has been synthesized by two routes. Attempts to hydrogenolyse or dehydrate the 2-hydroxy derivative were unsuccessful, however. Radical sulfonation of 3-amino-1-bromo-2-(4-chlorophenyl) propene gave 3-amino-2- (4-chlorophenyl)propene-1-sulfonic acid (6) which was readily reduced to (3). Alternatively, 2-(4-chlorophenyl)-3-phthalimidopropene underwent radical addition of thioacetic acid, and oxidation of the product to the sulfonyl chloride and hydrolysis gave (3). The corresponding sulfonamide (4) was also prepared. The acid (3) is a powerful specific antagonist of GABA at the GABAB receptor, while (4) and (6) are only weak antagonists. 
