
%0 Journal Article
%A Barlin, GB 
%A Tian, FL 
%A Kotecka, B 
%A Rieckmann, KH 
%T Potential Antimalarials. XVI. 4'-Chloro-3-[7&#8243;-chloro(and trifluoromethyl)quinolin-4&#8243;-yl]amino-5-(substituted amino)methylbiphenyl-4-ols and 4'-Bromo(and 3'-trifluoromethyl)-3-(substituted amino)methyl-5-(7&#8243;-trifluoromethylquinolin-4&#8243;-yl)aminobiphenyl-2-ols
%J Australian Journal of Chemistry
%D 1992/11/01
%V 45
%N 11
%P 1845-1855
%K 
%R https://doi.org/10.1071/CH9921845
%U https://www.publish.csiro.au/paper/CH9921845 
%X Twenty-four mono-Mannich bases of the general formulae 4'-chloro-3-[7&#8243;-chloro(and trifluoro-methyl)quinolin-4'-yl]amino-5-(substituted amino)methylbiphenyl-4-ols and 4'-bromo(and 3'- trifluoromethyl-3(substituted amino)methyl-5(7&#8243;-trifluoromethylquinolin-4&#8243;-yl) aminobiphenyl-2-ols have been prepared by condensation of the 4-chloro heterocycle with 5-amino-3-(N-substituted amino)methyl-4'-chlorobiphenyl-4-ols or 5-amino-3-(N-substituted amino)methyl- 4'-bromo(or 3'-trifluoromethyl)biphenyl-2-ols. The antimalarial activity of these products in in vitro tests against Plasmodium falciparum  reveals many with IC50 values of 50-100 nM ( chloroquine 20-40 nM ). The biphenyl-2-ols were more active than comparable biphenyl-4-ols. 
