
TY  - JOUR
A1  - Barlin, GB 
A1  - Tian, FL 
A1  - Kotecka, B 
A1  - Rieckmann, KH 
T1  - Potential Antimalarials. XVI. 4'-Chloro-3-[7&#8243;-chloro(and trifluoromethyl)quinolin-4&#8243;-yl]amino-5-(substituted amino)methylbiphenyl-4-ols and 4'-Bromo(and 3'-trifluoromethyl)-3-(substituted amino)methyl-5-(7&#8243;-trifluoromethylquinolin-4&#8243;-yl)aminobiphenyl-2-ols
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1992
VL  - 45
IS  - 11
SP  - 1845
EP  - 1855
KW  - 
UR  - https://doi.org/10.1071/CH9921845 
N2  - Twenty-four mono-Mannich bases of the general formulae 4'-chloro-3-[7&#8243;-chloro(and trifluoro-methyl)quinolin-4'-yl]amino-5-(substituted amino)methylbiphenyl-4-ols and 4'-bromo(and 3'- trifluoromethyl-3(substituted amino)methyl-5(7&#8243;-trifluoromethylquinolin-4&#8243;-yl) aminobiphenyl-2-ols have been prepared by condensation of the 4-chloro heterocycle with 5-amino-3-(N-substituted amino)methyl-4'-chlorobiphenyl-4-ols or 5-amino-3-(N-substituted amino)methyl- 4'-bromo(or 3'-trifluoromethyl)biphenyl-2-ols. The antimalarial activity of these products in in vitro tests against Plasmodium falciparum  reveals many with IC50 values of 50-100 nM ( chloroquine 20-40 nM ). The biphenyl-2-ols were more active than comparable biphenyl-4-ols. 
ER  -

