
TY  - JOUR
A1  - Hugel, HM 
A1  - Greenwood, RJ 
A1  - Mackay, MF 
T1  - 2-Hydroxyindole Compounds. Alkylation of 3-Acetyl-1-benzyl-2-hydroxy-5-,ethoxyindole Under Basic Conditions
JF  - Australian Journal of Chemistry
JO  - Aust. J. Chem.
Y1  - 1992
VL  - 45
IS  - 12
SP  - 1953
EP  - 1959
KW  - 
UR  - https://doi.org/10.1071/CH9921953 
N2  - Alkylation of 3-acetyl-1-benzyl-2-hydroxy-5-methoxyindole with benzyl bromide in the presence of base resulted in isolation of the C- alkylated product which has been shown by X-ray crystallographic analysis to be 3-acetyl-1,3-dibenzyl-5-methoxy-1,3-dihydro-2H-indol-2-one (5c) in accord with the spectroscopic data. Triclinic crystals of (5c) belong to the space group P1 with a 10.649(3), b 13.736(3), c 14.555(2) &#506;, &#945;: 86-73(2), &#946; 85.98(2), &#947; 78-01(2)&#176; and Z 4. Least-squares refinement with 1996 observed data converged at R 0.061. Molecular mechanics was used to calculate the minimum-energy structure of (5c) which is compared with the X-ray results. 
ER  -

